2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-130872A
    HS-PEG5-CH2CH2NH2 hydrochloride 1446256-16-1 98.0%
    HS-PEG5-CH2CH2NH2 hydrochloride is a PROTAC linker and belongs to the PEG class. Can be used to synthesize PROTAC molecules.
    HS-PEG5-CH2CH2NH2 hydrochloride
  • HY-140689
    m-PEG-mal (MW 2000)
    m-PEG-mal (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG-mal (MW 2000)
  • HY-140803
    Azide-PEG12-alcohol 1821464-55-4 99.81%
    Azide-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG12-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG12-alcohol
  • HY-W041970
    Ethyl 6-bromohexanoate 25542-62-5 99.93%
    Ethyl 6-bromohexanoate is a linker that can be used to synthesize PROTAC RSS0680 (HY-148062).
    Ethyl 6-bromohexanoate
  • HY-W041856
    N-Boc-8-amino-octanoic acid 30100-16-4
    N-Boc-8-amino-octanoic acid (Boc-8-aminooctanoic acid) can be used as a PROTAC linker in the synthesis of PROTACs. N-Boc-8-amino-octanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
    N-Boc-8-amino-octanoic acid
  • HY-W002042
    7-Aminoheptanoic acid 929-17-9 98.0%
    7-Aminoheptanoic acid is a PROTAC linker. 7-Aminoheptanoic acid can be used to synthesize PROTAC molecules (e.g. HL-8 (HY-143275)).
    7-Aminoheptanoic acid
  • HY-140651
    Amine-PEG-thiol (MW 2000)
    Amine-PEG-thiol (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amine-PEG-thiol (MW 2000)
  • HY-138469
    NH2-PEG3-C6-Cl 1261350-60-0
    NH2-PEG3-C6-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG3-C6-Cl
  • HY-141233
    Dodecaethylene glycol 6790-09-6 99.93%
    Dodecaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Dodecaethylene glycol
  • HY-124780
    HOOCCH2O-PEG4-CH2COOH 77855-75-5 98.0%
    HOOCCH2O-PEG4-CH2COOH, compound 5, is a symmetric PEG linker, used for the synthesis of the first class of Homo-PROTAC.
    HOOCCH2O-PEG4-CH2COOH
  • HY-140454
    Azido-PEG8-acid 1214319-92-2 98.0%
    Azido-PEG8-acid is a non-cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG8-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG8-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG8-acid
  • HY-138525
    Azido-PEG4-Thiol 2720615-82-5
    Azido-PEG4-Thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-Thiol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-Thiol
  • HY-W006635
    Bpin-Cyclohexene-COOEt 1049004-32-1
    Bpin-Cyclohexene-COOEt (Ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-cyclohexene-1-carboxylate) is a PROTAC linker belonging to the PEG class. Bpin-Cyclohexene-COOEt can be used to synthesize PROTAC molecules.
    Bpin-Cyclohexene-COOEt
  • HY-Y0786
    1,3-Dibromo-5,5-dimethylhydantoin 77-48-5 99.20%
    1,3-Dibromo-5,5-dimethylhydantoin is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    1,3-Dibromo-5,5-dimethylhydantoin
  • HY-116027
    Biotin-PEG3-acid 252881-76-8 98.0%
    Biotin-PEG3-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG3-acid
  • HY-140256
    NH-bis(PEG2-C2-Boc) 1964503-36-3 ≥98.0%
    NH-bis(PEG2-C2-Boc) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH-bis(PEG2-C2-Boc)
  • HY-141022
    Bis-PEG14-acid 98.0%
    Bis-PEG14-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-PEG14-acid
  • HY-141101
    Fmoc-PEG12-NHS ester 2227246-92-4 98.0%
    Fmoc-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-PEG12-NHS ester
  • HY-130589
    Bromo-PEG2-bromide 31255-10-4 99.25%
    Bromo-PEG2-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Bromo-PEG2-bromide
  • HY-141238
    HO-PEG24-OH 2243942-52-9 99.89%
    HO-PEG24-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    HO-PEG24-OH
PROTAC Linkers Isoform Comparison

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